Small cell lung cancer (SCLC) is behind 15% of lung cancers. The disease can be aggressive with poor prognosis and early metastasis. Until recently, small-cell lung cancer treatment options didn’t change, and chemotherapy is becoming a cornerstone treatment option. The overview highlights recent advancements in the staging field, systematic treatment, and radiotherapy. Nevertheless, new treatment options are necessary. We will discuss the progress of systematic treatment after repurposing current drugs with targeted treatment.